Fig. 8

Optos widefield fundus imaging of the right (A) and left eye (B), showing features of proliferative diabetic retinopathy (PDR), such as new vessels along the temporal vascular arcades, venous beading and loops, dot and blot hemorrhages, and hard exudates. Fluorescein angiography at 12 min in the right (C) and at 1 min in the left eye (D) showing both features of PDR such as capillary non-perfusion, leakage from new vessels, and microaneurysms, as well as features from Macular Telangiectasia Type 2 (MacTel2), such as temporal para- and perifoveal leakage from telangiectatic, right-angled vessels. Optical coherence tomography (OCT) of the right eye (E) showing subretinal fluid, temporal macular thickening, intraretinal fluid and hyperreflective dots corresponding with hard exudates on fundus imaging. Optical coherence tomography (OCT) of the left eye (F) shows focal outer retinal atrophy and angular hyperreflectivity of the Henle fiber layer. En face optical coherence tomography angiography (OCTA) of the superficial (G), and (H) deep capillary plexus, and (I) the avascular segmentation slab showing telangiectatic right-angled vessels, anastomoses and rarefaction of the surrounding capillary bed in line with MacTel2