- Case report
- Open Access
Idiopathic full thickness macular hole in a 10-year-old girl
International Journal of Retina and Vitreous volume 4, Article number: 25 (2018)
Macular holes in children are generally associated with trauma.
We report the first case of an idiopathic full thickness macular hole in a 10-year-old girl. 23-gauge transconjunctival pars plana vitrectomy, induction of a posterior vitreous detachment, ILM blue-assisted internal limiting membrane peel, fluid–air exchange and air-26% sulfur hexafluoride (SF6) exchange was performed with subsequent macular hole closure.
This is the first reported case of an idiopathic full thickness macular hole in a child. Treatment with pars plana vitrectomy with peeling of the ILM resulted in significant anatomic and functional improvement.
A macular hole is a full thickness defect in the neural retina at the fovea. It is thought to occur as a result of pathological changes at the foveal vitreoretinal interface . Idiopathic macular holes most commonly occur in adults in the 6th to 7th decade . Macular holes in children are rare and are generally associated with trauma . We present a case of an idiopathic full thickness macular hole (FTMH) in a child.
A 10-year-old girl presented with reduced vision in the right eye. The vision had deteriorated from 20/17 1 year previously, to 20/60. She was otherwise well, with no history of trauma or inflammation of either eye and no other significant medical or drug history. Her grandfather, and grandfather’s brother had a history of retinal detachment.
Visual acuity (VA) was 20/60 in the right eye and 20/20 in the left eye. Ocular examination was unremarkable except for the presence of a FTMH in the right eye (Fig. 1). There was no evidence of trauma, inflammation or signs of retinal dystrophy. Optical coherence tomography (OCT) showed a 365 μm FTMH with no vitreomacular traction or posterior vitreous detachment (Fig. 2).
Following informed consent of her parents, we carried out a 23-gauge transconjunctival pars plana vitrectomy. Induction of a posterior vitreous detachment (PVD) was completed using triamcinolone, followed by ILM blue-assisted internal limiting membrane (ILM) peel, fluid–air exchange and air-26% sulfur hexafluoride (SF6) exchange. She was positioned face down for 3 days postoperatively. At postoperative week 1, VA was 20/60 with OCT evidence of hole closure (Fig. 3). At postoperative month 1, VA was 20/20, and at 4 months postoperative, the macular hole remained closed with remodeling of the outer retina on OCT (Fig. 4). There was still a small defect at the photoreceptor level.
There is only one previous report in the current literature of an idiopathic FTMH in a child. This case however, had features of cavitary maculopathy and did not have a full thickness defect .
In our case, the patient and her family were very reliable historians, strongly denying any possibility of antecedent trauma. Excellent vision of 20/17 was documented just 1 year prior by her optometrist. However, despite this, we must acknowledge, that given the active nature of children it is possible that an unreported trauma may have occurred in our case. Children often do not immediately report their recent behaviors or visual symptoms, possibly out of fear of retribution or simply a lack of understanding. In addition, the possibility of non-accidental injury should always be considered as other life-threatening injuries and or situations may also be present.
In the setting of blunt trauma, the most common cause of macular hole in children, a contrecoup mechanism as a result of axial globe compression is thought to increase vitreomacular traction forces . Our case illustrates an idiopathic FTMH in a child, in which neither vitreomacular separation or vitreofoveal traction could be visualized clinically or on OCT. The mechanism of idiopathic FTMH formation in a child remains unclear.
Review of the English language literature identified 15 pediatric eyes with a non-traumatic macular hole (Table 1). In contrast to our case, all had clinical or historical features of a secondary non-traumatic cause including: vascular (retinopathy of prematurity (ROP) , and Coats’ disease [7, 8]), infective (Bartonella neuroretinitis [9,10,11]), and congenital (choroidal coloboma , regressed Bergmeister papilla ), and juvenile idiopathic epiretinal membrane ) entities. A case of accidental Nd:YAG laser induced macular hole in a child has also been reported, photothermal and photomechanical disruption of the retina occurring as a result of energy absorbed by the retinal pigment epithelium (RPE) . The patients with ROP all had vitreoretinal surgery prior to discovery of the macular hole, and all had an associated retinal detachment. They were treated with a combination of open and closed vitrectomy in addition to a radial scleral buckle . Of the 15 eyes, surgical hole closure was attempted in 9 cases. Apart from the patients with ROP, the other 5 cases were treated with vitrectomy, ILM peel and gas tamponade. Anatomic closure of the hole was reported in all 5 cases [4, 7, 13,14,15].
Macular surgery in the pediatric population has unique management and technical challenges. As previously mentioned, it may be difficult to accurately and reliably date how long the macular hole has been present. This poses a challenge when attempting to predict the presence of any contributory amblyopia to the presenting vision, and the potential visual benefit that can be expected from surgery. Induction of a PVD is difficult in children, and use of triamcinolone as in our case, may augment visualization of the posterior hyaloid. Fortunately for this patient, induction of the PVD was similar to that in an adult. Secondary complications including iatrogenic retinal tears and vitreous hemorrhage as a result of a young, adherent posterior hyaloid, in addition to late complications including vitrectomy induced cataract, should be considered carefully.
Finally, the ability to comply with post-operative care and practices including possible face down positioning are important in the pre-operative assessment of a child for macular surgery. Interestingly 3 cases specifically reported instructing their patient to position prone in the post-operative period [4, 13, 15]. These patients were of similar age to our patient, and also achieved macular hole closure.
This is the first reported case of an idiopathic FTMH in a child. Treatment with pars plana vitrectomy with peeling of the ILM resulted in significant anatomic and functional improvement.
full thickness macula hole
optical coherence tomography
posterior vitreous detachment
internal limiting membrane
retinopathy of prematurity
retinal pigment epithelium
Alexandre de Amorim Garcia Filho C, Yehoshua Z, Gregori G, et al. Optical coherence tomography. In: Schachat A, Wilkinson C, Hinton D, et al., editors. Ryan’s Retina, vol. 1. 5th ed. Beijing: Saunders; 2013. p. 89.
American Academy of Ophthalmology Retina/Vitreous Panel. Preferred practice pattern®guidelines. Idiopathic macular hole. San Francisco: American Academy of Ophthalmology; 2014. www.aao.org/ppp.
Huang J, Liu X, Wu Z, et al. Comparison of full-thickness traumatic macular holes and idiopathic macular holes by optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2010;248:1071–5.
Park JC, Frimpong-Ansah KN. Idiopathic macula hole in a child. Eye. 2012;26:620–1.
Johnson RN, McDonald R, Lewis H, et al. Traumatic macular hole: observations, pathogenesis, and results of vitrectomy surgery. Ophthalmology. 2001;108:853–7.
Ahmad OF, Hirose T. Retinal detachment with macular holes in infants with retinopathy of prematurity. Arch Ophthalmol. 2005;123:54–7.
Wong SC, Neuwelt MD, Tresse MT. Delayed closure of paediatric macular hole in Coats’ disease. Acta Ophthalmol. 2012;90:e326–7.
Kumar V, Neha G, Basudeb G. Full-thickness macular hole and macular telangiectasia in a child with coats’ disease. Ophthalmic Surg Lasers Imaging. 2010;30:41.
Albini TA, Lakhanpal RR, Foroozan R, et al. Macular hole in cat scratch disease. Am J Ophthalmol. 2005;140(1):149–51.
Donnio A, Jean-Charles A, Merle H. Macular hole following Bartonella henselae neuroretinitis. Eur J Ophthalmol. 2008;18(3):456–8.
Seth A, Raina UK, Thirumalai S, et al. Full-thickness macular hole in Bartonella henselae neuroretinitis in an 11-year-old girl. Oman J Ophthalmol. 2015;8(1):44–6. https://doi.org/10.4103/0974-620x.149866.
Bansal P, Chawla R, Sharma A. Pediatric choroidal coloboma with macular hole at the edge of the coloboma. Ophthalmology. 2017;124(5):666.
Nakano T, Uemura A, Kanda S, et al. A nontraumatic macula hole in a 10-year-old girl. Jpn J Ophthalmol. 2005;49:520–2.
Yokoyama T, Watanabe Y, Murakami A. Macular hole secondary to epiretinal membrane in a juvenile patient. Am J Ophthalmol. 2005;139:357–9.
Fernandez MP, Modi YS, John VJ, et al. Accidental Nd:YAG laser-induced macular hole in a paediatric patient. Ophthalmic Surg Lasers Imaging Retina. 2013;44:e7–10.
JG reviewed the patient at first presentation. AH and GF performed surgery and post-operative care. LL and SL collated and prepared the patient data. LL was a major contributor in writing the manuscript. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Availability of data and materials
The data in the current case report are available from the Sydney Eye Hospital and Save Sight Institute medical records. The data is available from the corresponding author on reasonable request.
Consent for publication
Consent for publication was obtained.
Ethics approval and consent to participate
Ethics approval for this research was obtained (South Eastern Sydney Local Health District Human Research Ethics Committee, HREC Ref Number: 17/232 LNR/17/POWH/529) SSA Ref 18/G/019). Consent for participation was obtained.
Drs Fernandez and Levasseur received funding from the Sydney Eye Hospital Foundation.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Lim, L.S., Fernandez-Sanz, G., Levasseur, S. et al. Idiopathic full thickness macular hole in a 10-year-old girl. Int J Retin Vitr 4, 25 (2018). https://doi.org/10.1186/s40942-018-0128-9
- Macular hole