Articles

Consequences of inadvertent intravitreal Mitomycin C injection

Mitomycin C (MMC) as an alkylating agent is miscellaneous an antineoplastic, antibiotic and ophthalmic agent. Here we aim to report a case of inadvertent intravitreal MMC injection instead of Avastin in case o...

Authors: Ahmad Mirshahi, Alireza Lashay, Mohammad Reza Mehrabi Bahar and Mojtaba Abrishami

Early changes in macular optical coherence tomography parameters after Ranibizumab intravitreal injection in patients with exsudative age-related macular degeneration

Evaluation of the impact of different macular optical coherence parameters on visual acuity as early as 1 day after injection of ranibizumab in patients with subfoveal exsudative age-related macular degeneration.

Authors: Nicole Antunes de Almeida and Osias Francisco de Souza

Comparative analysis of choroidal thickness in third trimester pregnant women

The impact of pregnancy on the choroid is still under investigation. The aim of this study is to compare choroidal thickness measurements of healthy pregnant women in the third trimester and healthy non-pregna...

Authors: Camila Zanella Benfica, Teresinha Zanella, Lucas Brandolt Farias, Maria Lúcia Rocha Oppermann, Luis Henrique Santos Canani and Daniel Lavinsky

Macular pigment optical density in a Brazilian sample

To evaluate macular pigment optical density (MPOD) and to identify its determinants in a sample of Brazilian individuals.

Authors: Letícia Pinto Coelho Jorge, Carlos Eduardo Gonçalves Pereira, Eduardo Jorge and Marcos Pereira de Ávila

Jules Gonin and the Nobel Prize: pioneer of retinal detachment surgery who almost received a Nobel Prize in medicine

Authors: Fábio Barreto Morais

Feasibility of using experimental high viscosity silicone oils: a pilot study

Polydimethyl silicones (silicone oils) are used in complex retinal surgeries, including difficult or recurrent retinal detachments, severe eye trauma, and other indications for long term tamponade. Two major ...

Authors: Shira Sheen-Ophir, Mordechai Rosner and Alexander Rubowitz

Autoimmune retinopathy: A Review

Autoimmune retinopathy (AIR) is a rare and still poorly understood immune-mediated disease that may cause inflammation from circulating autoantibodies against the retina. It may be related to history of autoim...

Authors: Aristófanes Mendonça Canamary Jr., Walter Yukihiko Takahashi and Juliana Maria Ferraz Sallum

Idiopathic macular telangiectasis type 2 and co-existent diabetic retinopathy

To study the interaction between idiopathic macular telangiectasis type 2 (MacTel2) and coexistent diabetic retinopathy (DR) during long term follow up.

Authors: Mahima Jhingan, Kerul Marsonia, Dhananjay Shukla, Philip J. Rosenfeld and Jay Chhablani

Retinal malperfusion in albuminuric Type 1 diabetes mellitus patients without clinical signs of diabetic retinopathy: a prospective pilot study

To report fluorescein angiography findings in a group of albuminuric Type 1 diabetes mellitus (T1DM) patients without diabetic retinopathy.

Authors: Fernando Korn Malerbi, Caio Vinicius Regatieri, João Roberto de Sa, Paulo Henrique Morales, Michel Eid Farah and Sergio Atala Dib

Recurrence rate and need for reoperation after surgery with or without internal limiting membrane removal for the treatment of the epiretinal membrane

To compare the recurrence rate and need for reoperation after epiretinal membrane surgery with and without removal of the internal limiting membrane.

Authors: Fernando José De Novelli, Mauro Goldbaum, Mario Luiz Ribeiro Monteiro, Fabio Bom Aggio, Mario Junqueira Nóbrega and Walter Yukihiko Takahashi

Primary rhegmatogenous retinal detachment with inferior retinal breaks postoperative prone positioning results: 1 day versus 7 days

To compare the primary anatomical outcome of pars plana vitrectomy, 360° peripheral endolaser, and 15% octafluoropropane C₃F₈ gas tamponade in patients with uncomplicated rhegmatogenous detachment and inferior re...

Authors: Radwan Ajlan, Jordan Isenberg, Ghassan Cordahi, Renaud Duval, Sébastien Olivier and Flavio Rezende

Subretinal fluid application to close a refractory full thickness macular hole

To close a refractory full thickness macular hole (FTMH) by adjacent subretinal fluid application to release the elastic retina from the retinal pigment epithelium (RPE).

Authors: Carsten H. Meyer, Robert Borny and Nicole Horchi

Heads-up 3D vision system for retinal detachment surgery

Here we present procedural and safety results from our initial experience using 3D heads-up vitrectomy for retinal detachment surgery. The comparison with our outcomes from previous standard surgery shows how ...

Authors: Michele Coppola, Carlo La Spina, Alessandro Rabiolo, Giuseppe Querques and Francesco Bandello

Parafoveolar retinoblastoma regression with foveal preservation following intra-arterial chemotherapy documented on hand-held optical coherence tomography in a newborn

Optical coherence tomography (OCT) has become an invaluable tool in retinoblastoma management, providing submillimeter visualization of tumor control following treatment. Herein, we document OCT-detection of a...

Authors: Vera Yarovaya, Kareem Sioufi and Carol L. Shields

Outcomes of primary endoresection for choroidal melanoma

To review long time treatment results in patients with small or medium sized choroidal melanoma who underwent surgical tumor endoresection as a primary treatment when plaque radiotherapy was unable and patient...

Authors: Andre A. C. Vidoris, Andre Maia, Marcia Lowen, Melina Morales, Jordan Isenberg, Bruno F. Fernandes and Rubens N. Belfort

Development of a new tissue injector for subretinal transplantation of human embryonic stem cell derived retinal pigmented epithelium

Subretinal cell transplantation is a challenging surgical maneuver. This paper describes the preliminary findings of a new tissue injector for subretinal implantation of an ultrathin non-absorbable substrate ...

Authors: Rodrigo A. Brant Fernandes, Francisco R. Stefanini, Paulo Falabella, Michael J. Koss, Trent Wells, Bruno Diniz, Ramiro Ribeiro, Paulo Schor, Mauricio Maia, Fernando M. Penha, David R. Hinton, Yu-Chong Tai and Mark Humayun

Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide

Ophthalmic artery chemosurgery [OAC, intra-arterial chemotherapy (IAC)] was introduced in 2006 as treatment modality for intraocular retinoblastoma. The purpose of this commentary is to retrospectively review ...

Authors: David H. Abramson, Carol L. Shields, Pascal Jabbour, Luiz Fernando Teixeira, José Roberto Falco Fonseca, Marcio Chaves Pedro Marques, Francis L. Munier, Francesco Puccinelli, Theodora Hadjistilianou, Sandra Bracco, Guillermo Chantada, Alejandro Ceciliano and Y. Pierre Gobin

Correction to: pH of anti-VEGF agents in the human vitreous: low impact of very different formulations

After the publication of this article [1], we were made aware that the osmolarity of aflibercept (Eylea) was incorrect and should have been 286 mOsm and not 1000 mOsm. The correct version of Table 1 is shown in t...

Authors: Bianka Sobolewska, Peter Heiduschka, Karl‑Ulrich Bartz‑Schmidt and Focke Ziemssen

Anatomical and functional correlation in Susac syndrome: multimodal imaging assessment

Susac’s syndrome (SuS) is an uncommon disease characterized by retinal microangiopathy that may be assessed more accurately with optical coherence tomography angiography (OCTA), a new imaging technique which p...

Authors: Alexandre G. B. Azevedo, Luiz H. Lima, Léo Müller, Flávio Rezende Filho, Cláudio Zett, André Maia and Luiz Roisman

Twenty-seven-gauge vitrectomy for combined tractional and rhegmatogenous retinal detachment involving the macula associated with proliferative diabetic retinopathy

To report our experience using 27-gauge pars plana vitrectomy (PPV) system for treating patients with combined tractional and rhegmatogenous retinal detachments (CTRRD) involving the macula associated with pro...

Authors: Yousef J. Cruz-Iñigo and María H. Berrocal

Vitrectomy in high myopia: a narrative review

Pathologic myopia is associated with degenerative changes of the globe, especially at the posterior pole. Eyes affected by pathologic myopia have higher odds to undergo posterior segment surgery and, in those ...

Authors: Michele Coppola, Alessandro Rabiolo, Maria Vittoria Cicinelli, Giuseppe Querques and Francesco Bandello

Optical coherence tomography findings in methanol toxicity

Methanol toxicity poses a significant public health problem in developing countries, and in Southeast Asia, where the most common source of poisoning is via adulterated liquor in local drinks. Methanol toxici...

Authors: Kendra A. Klein, Alexis K. Warren, Caroline R. Baumal and Thomas R. Hedges III

Incontinentia pigmenti in a child with suspected retinoblastoma

Incontinentia pigmenti is a rare X-linked dominant syndrome caused by mutation in the NEMO/IKKgamma gene, and characterized by a spectrum of cutaneous, ocular, neurologic and dental abnormalities. In the eye, ...

Authors: Stephanie J. Weiss, Archana Srinivasan, Michael A. Klufas and Carol L. Shields

Gene panel sequencing in Brazilian patients with retinitis pigmentosa

Retinal dystrophies constitute a group of diseases characterized by clinical variability and pronounced genetic heterogeneity. Retinitis pigmentosa is the most common subtype of hereditary retinal dystrophy an...

Authors: Kárita Antunes Costa, Mariana Vallim Salles, Chris Whitebirch, John Chiang and Juliana Maria Ferraz Sallum

Book Review: Anti-VEGF Use in Ophthalmology

This is a review of a book entitled, “Anti-VEGF Use in Ophthalmology,” written by Jay Duker, MD and Michelle Liang, MD. It is an excellent description of the history and development of anti-VEGF agents as wel...

Authors: Robin A. Vora

Net technique for intraocular lens support in aphakia without capsular support

This paper describes a modified surgical technique for intraocular lens implantation in aphakic eyes with no capsular support.

Authors: Fernando José De Novelli, Theodomiro Lourenço Garrido Neto, Gabriel de Sena Rabelo, Marcel Eduardo Blumer, Ricardo Suzuki and Ramon Coral Ghanem

Retinal and choroidal angiogenesis: a review of new targets

Retinal and choroidal neovascularization are a major cause of significant visual impairment, worldwide. Understanding the various factors involved in the accompanying physiopathology is vital for development o...

Authors: Thiago Cabral, Luiz Guilherme M. Mello, Luiz H. Lima, Júlia Polido, Caio V. Regatieri, Rubens Belfort Jr. and Vinit B. Mahajan

Giant retinal tear after intra-arterial chemotherapy for advanced unilateral retinoblastoma

Retinoblastoma is considered the most common intraocular malignancy in childhood, comprising 4% of all pediatric cancers. Management of retinoblastoma has evolved over the past two decades and intra-ophthalmic...

Authors: Camila V. Ventura, Audina M. Berrocal, Jennifer Thomson, Fiona J. Ehlies, Azeema Latiff and Timothy G. Murray

Structure versus function: correlation between outer retinal and choroidal thicknesses measured by swept-source OCT with multifocal electroretinography and visual acuity

To correlate retina-choroidal anatomy as assessed via swept-source OCT (SS-OCT) with retinal function as determined by best-corrected visual acuity (BCVA) and multifocal electroretinogram (mfERG).

Authors: Ignacio Flores-Moreno, Luis Arias-Barquet, Marcos J. Rubio-Caso, Alex Muñoz-Blanco, María Vidal-Martí, Jaume Catala-Mora, José M. Ruiz-Moreno, Jay S. Duker and Josep M. Caminal

Evaluation of macular and peripapillary vessel flow density in eyes with no known pathology using optical coherence tomography angiography

To assess normal vessel flow density (VFD) in macular and peripapillary regions of eyes with no known ocular pathology using optical coherence tomography angiography (OCTA).

Authors: Muhammad Hassan, Mohammad Ali Sadiq, Muhammad Sohail Halim, Rubbia Afridi, Mohamed K. Soliman, Salman Sarwar, Aniruddha Agarwal, Diana V. Do, Quan Dong Nguyen and Yasir Jamal Sepah

Un-explained visual loss following silicone oil removal: results of the Pan American Collaborative Retina Study (PACORES) Group

To report the incidence and clinical features of patients that experienced un-explained visual loss following silicone oil (SO) removal.

Authors: Jose A. Roca, Lihteh Wu, Maria Berrocal, Francisco Rodriguez, Arturo Alezzandrini, Gustavo Alvira, Raul Velez-Montoya, Hugo Quiroz-Mercado, J. Fernando Arevalo, Martín Serrano, Luiz H. Lima, Marta Figueroa, Michel Farah and Giovanna Chico

Segmentation errors in macular ganglion cell analysis as determined by optical coherence tomography in eyes with macular pathology

To evaluate artifacts in macular ganglion cell inner plexiform layer (GCIPL) thickness measurement in eyes with retinal pathology using spectral-domain optical coherence tomography (SD OCT).

Authors: Rayan A. Alshareef, Abhilash Goud, Mikel Mikhail, Hady Saheb, Hari Kumar Peguda, Sunila Dumpala, Shruthi Rapole and Jay Chhablani

Macular findings in Spectral Domain Optical Coherence Tomography and OCT Angiography in a patient with Kearns–Sayre syndrome

To report the clinical, electrophysiological and the anatomical findings in a patient with Kearns–Sayre syndrome (KSS).

Authors: Alvaro Ortiz, Juan Arias, Pedro Cárdenas, John Villamil, Marcela Peralta, Luis C. Escaf and Jacobo Ortiz

Patient pain during intravitreal injections under topical anesthesia: a systematic review

Intravitreal injection (IVI) is a very common vitreoretinal procedure, and multiple injections are often required per patient. This systematic review was conducted to evaluate the effectiveness of various loca...

Authors: Helio Francisco Shiroma, Augusto Key Karazawa Takaschima, Michel Eid Farah, Ana Luisa Höfling-Lima, Graziela de Luca Canto, Roberto Henrique Benedetti and Eduardo Buchele Rodrigues

pH of anti-VEGF agents in the human vitreous: low impact of very different formulations

The aim of the study was to measure pH changes of the human vitreous caused by the intravitreal drugs bevacizumab, ranibizumab, aflibercept, and ziv-aflibercept.

Authors: Bianka Sobolewska, Peter Heiduschka, Karl-Ulrich Bartz-Schmidt and Focke Ziemssen

Visualization of changes in the foveal avascular zone in both observed and treated diabetic macular edema using optical coherence tomography angiography

Central vision loss in diabetic retinopathy is commonly related to diabetic macular edema (DME). The objective of this study was to describe changes between consecutive visits on optical coherence tomography a...

Authors: Aditya Gill, Emily D. Cole, Eduardo A. Novais, Ricardo N. Louzada, Talisa de Carlo, Jay S. Duker, Nadia K. Waheed, Caroline R. Baumal and Andre J. Witkin

The comparison of multimodal imaging findings of central serous chorioretinopathy patients in regard to the early anatomically treatment response to half-fluence photodynamic therapy: a retrospective case–control study

To compare the multimodal imaging findings of chronic central serous chorioretinopathy (CSC) patients who are good or poor responders to low-fluence photodynamic therapy (PDT).

Authors: Abdullah Ozkaya, Ruveyde Garip, Zeynep Alkin and Muhittin Taskapili

Book review: spectral domain optical coherence tomography in macular diseases

This is a review of the book Spectral Domain Optical Coherence Tomography in Macular Diseases edited by Meyer et al. (Spectral domain optical coherence tomography in macular diseases. Springer, New York, [2017])....

Authors: Müller Gonçalves Urias and Eduardo Büchele Rodrigues

Gamma knife radiosurgery for the treatment of uveal melanoma and uveal metastases

This study retrospectively analyzed outcomes for patients undergoing gamma knife radiosurgery (GKR) for uveal melanoma (UM) and intraocular metastases.

Authors: Margaret M. Reynolds, Andrea L. Arnett, Ian F. Parney, Ravi Kumar, Nadia N. Laack, Patrick R. Maloney, Timothy F. Kozelsky, Yolanda I. Garces, Robert L. Foote and Jose S. Pulido

Choroidal vascular analysis in myopic eyes: evidence of foveal medium vessel layer thinning

To analyse morphologic features of the choroid in Non-pathological myopic eyes using spectral-domain (SD) optical coherence tomography (OCT).

Authors: Rayan A. Alshareef, Mohammed K. Khuthaila, Manideepak Januwada, Abhilash Goud, Daniela Ferrara and Jay Chhablani

Visual rehabilitation via microperimetry in patients with geographic atrophy: a pilot study

Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. As a consequence of AMD, patients develop structural damage that comprises the fovea and subsequently present loss...

Authors: Juan Abel Ramírez Estudillo, Mario Isaías León Higuera, Sergio Rojas Juárez, Maria de Lourdes Ordaz Vera, Yessica Pablo Santana and Benito Celis Suazo

Impact of image quality on OCT angiography based quantitative measurements

To study the impact of image quality on quantitative measurements and the frequency of segmentation error with optical coherence tomography angiography (OCTA).

Authors: Mayss Al-Sheikh, Khalil Ghasemi Falavarjani, Handan Akil and SriniVas R. Sadda

Correlation between retinal function and microstructural foveal changes in intermediate age related macular degeneration

To assess foveal microstructural changes influencing retinal sensitivity (RS) and fixation stability using microperimeter MP-1 in intermediate age-related macular degeneration (AMD).

Authors: Serena Fragiotta, Carmela Carnevale, Alessandro Cutini and Enzo Maria Vingolo

Aqueous vascular endothelial growth factor and clinical outcomes correlation after single intravitreal injection of bevacizumab in patients with neovascular age-related macular degeneration

To evaluate the concentration of vascular endothelial growth factor (VEGF) in aqueous humor after a single intravitreal injection of bevacizumab (IVB) in eyes with neovascular age-related macular degeneration...

Authors: Thiago Cabral, Luiz H. Lima, Júlia Polido, Jimmy Duong, Érika Okuda, Akiyoshi Oshima, Pedro Serracarbassa, Caio V. Regatieri and Rubens Belfort Jr

Macular edema is a rare finding in untreated vitreoretinal lymphoma: small case series and review of the literature

To determine the occurrence of macular edema (ME) in vitreoretinal lymphoma (VRL).

Authors: Elisa Carreras, Diva R. Salomão, Jeroni Nadal, Sejal R. Amin, Harish Raja, Thomas J. Grube, Ryan L. Geraets, Patrick B. Johnston, Brian P. O’Neill and Jose S. Pulido

Characteristics and racial variations of polypoidal choroidal vasculopathy in tertiary centers in the United States and United Kingdom

To evaluate the characteristics and racial variations amongst patients with polypoidal choroidal vasculopathy (PCV) in the United States and the United Kingdom.

Authors: Tarek Alasil, Nelida Munoz, Pearse A. Keane, Adnan Tufail, Patrick A. Coady, Eduardo Novais, Talisa E. de Carlo, Caroline R. Baumal, Nadia K. Waheed, Jay S. Duker and Ron A. Adelman

Bilateral retinitis following typhoid fever

Post typhoid fever immune related reactions affecting the eye is a rare finding which can have various presentations in which typhoid retinopathy is not a well recognized sequelae.

Authors: M. Prabhushanker, Tasneem T. Topiwalla, Geetha Ganesan and Sripal Appandaraj

Effect of intravitreal aflibercept on recalcitrant diabetic macular edema

Despite anti-VEGF therapy, some patients develop chronic diabetic macular edema. The objective of this study was to evaluate anatomic and visual outcomes of switching patients with chronic DME from intravitre...

Authors: Kendra A. Klein, Tina S. Cleary and Elias Reichel

Circumferential silicone sponge scleral buckling induced axial length changes: case series and comparison to literature

This study compared axial length changes induced by circumferential scleral buckling using a silicone sponge with literature reports for solid silicone rubber.

Authors: Shira Sheen Ophir, Asaf Friehmann and Alexander Rubowitz

Multi-modal imaging and anatomic classification of the white dot syndromes

The white dot syndromes (WDS) are a diverse group of posterior uveitidies that share similar clinical findings but are unique from one another. Multimodal imaging has allowed us to better understand the morpho...

Authors: Meisha L. Raven, Alexander L. Ringeisen, Yoshihiro Yonekawa, Maxwell S. Stem, Lisa J. Faia and Justin L. Gottlieb