Articles

Clinical course of acute zonal occult outer retinopathy complicated by choroidal neovascularization

To report the clinical course and multimodal imaging features of acute zonal occult outer retinopathy (AZOOR) complicated by choroidal neovascularization (CNV) treated with anti-vascular endothelial growth fac...

Authors: Ugo Introini, Giuseppe Casalino, Elona Dhrami-Gavazi, Sri Krishna Mukkamala, Sarah Mrejen, Hermann Schubert, Salomon Y. Cohen, Claudio Azzolini, Francesco Bandello, Stanley Chang and Lawrence A. Yannuzzi

Direct navigated laser photocoagulation as primary treatment for retinal arterial macroaneurysms

To compare the efficacy and safety of conventional and navigated laser photocoagulation as the primary treatment option for retinal arteriolar macroaneurysm (RAM).

Authors: Dmitrii S. Maltsev, Alexei N. Kulikov, Bhushan Uplanchiwar, Luiz H. Lima and Jay Chhablani

Multimodal imaging in choroidal osteoma

To describe characteristics of choroidal osteomas (CO), using ocular ultrasound, fluorescein angiography, ultra-widefield retinal imaging, ultra-widefield autofluorescence, optical coherence tomography, enhanc...

Authors: Francisco Olguin-Manríquez, Ana Bety Enríquez, Nicolás Crim, Miroslava Meraz-Gutierrez, Vidal Soberón-Ventura, Ismael Ávila, Virgilio Morales-Canton and Juan Manuel Jimenez-Sierra

Sustained and targeted episcleral delivery of celecoxib in a rabbit model of retinal and choroidal neovascularization

To evaluate the efficacy of selective episcleral delivery of celecoxib formulated in a sustained-release episcleral exoplant on a model of retinal and choroidal neovascularization induced in rabbits by subreti...

Authors: Luiz H. Lima, Michel E. Farah, Glenwood Gum, Pamela Ko and Ricardo A. de Carvalho

Iodate induced toxic retinopathy: a case report

Iodine deficiency is a common preventable cause of intellectual and developmental disabilities. Iodine in the form of potassium iodate is added to the common salt under the National Iodine Deficiency Disorder ...

Authors: Y. C. Venu Gopal Reddy, Anuj Sharma, Adheesh P. Shetty and Syed Mohideen Abdul Kader

Acute retinal vein occlusion and cystic fibrosis

The ocular manifestations of cystic fibrosis typically present with surface irritation or nyctalopia due to Vitamin A deficiency, however, there have been two previous reports of patients with cystic fibrosis ...

Authors: Matthew R. Starr, Suzanne M. Norby, John P. Scott and Sophie J. Bakri

Idiopathic full thickness macular hole in a 10-year-old girl

Macular holes in children are generally associated with trauma.

Authors: Li-Anne S. Lim, Guillermo Fernandez-Sanz, Steven Levasseur, John R. Grigg and Alex P. Hunyor

Dexamethasone implant in silicone oil: in vitro behavior

To determine the effect of the silicone on the dexamethasone intravitreal implant.

Authors: Erick Omar Flores-Villalobos, J. Abel Ramírez-Estudillo, Atzin Robles-Contreras and Jacqueline L. Oliva-Ramírez

Gamma Knife radiosurgery for locally recurrent choroidal melanoma following plaque radiotherapy

For the majority of eyes with choroidal melanoma, radiation therapy is the treatment of choice. Local recurrence after radiation therapy can occur, however, and when it does, salvaging the globe with useful vi...

Authors: Osama A. Sorour, John E. Mignano and Jay S. Duker

The utility of ultra-widefield fluorescein angiography in pediatric retinal diseases

Ultra-widefield angiography is the latest technology in the evolution of fundus fluorescein angiography. With the ability to capture up to 200° of the fundus in a single image, far peripheral retinal pathology...

Authors: Charles M. Calvo and Mary Elizabeth Hartnett

Correction to: The diagnosis and treatment of primary vitreoretinal lymphoma: a review

Following publication of the original article [1], the authors reported that one of the authors’ name is spelled incorrectly. In this correction, the incorrect and correct author names are shown.

Authors: Jose S. Pulido, Patrick B. Johnston, Grzegorz S. Nowakowski, Alessia Castellino and Harish Raja

Incidence and risk factors for retinopathy of prematurity: a retrospective cohort study

Advances in neonatal care promoted increased survival rates of preterm infants, with a consequent increase in the number of children affected by retinopathy of prematurity (ROP). This study estimates the incid...

Authors: André Moraes Freitas, Ricardo Mörschbächer, Mariana R. Thorell and Ernani Luis Rhoden

Re: Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide

Authors: Sameh E. Soliman, Helen Dimaras, Brenda Gallie and Furqan Shaikh

Vinorelbine-induced regression of a choroidal metastasis from primary breast carcinoma

Various therapeutic options exist to treat choroidal metastatic lesions. However, they are all associated with potential long-term adverse effects. This case report discusses a case of choroidal metastasis fr...

Authors: Malvika Arya and Jay S. Duker

The diagnosis and treatment of primary vitreoretinal lymphoma: a review

To describe the recent diagnostic and treatment options for the most predominant form of primary vitreoretinal lymphoma (PVRL), namely diffuse large B cell lymphoma. This is mainly based on the experience at t...

Authors: Jose S. Pulido, Patrick B. Johnston, Grzegorz S. Nowakowski, Alessia Castellino and Harish Raja

Choroidal infarction following ophthalmic artery chemotherapy

Methylenetetrahydrofolate reductase (MTHFR) genetic mutations and intra-procedural inhaled nitrous oxide (N₂O) independently increase blood levels of homocysteine, a compound associated with thrombosis. Patients ...

Authors: Kelley J. Bohm, Y. Pierre Gobin, Jasmine H. Francis, Gabrielle McInerney, Anahita Dabo-Trubelja, Paul H. Dalecki, Brian P. Marr and David H. Abramson

Choroidal thickness changes measured by enhanced depth imaging optical coherence tomography in third trimester pregnant women

The aim of this article is to underline the effect of pregnancy on the variations of choroidal thickness caused by hormonal and haemodynamic changes.

Authors: Lorenzo Ferro Desideri, Fabio Barra, Simone Ferrero and Aldo Vagge

Comparison between optical coherence tomography angiography and fluorescein angiography findings in retinal vasculitis

To describe optical coherence tomography angiography (OCT-A) findings in patients with retinal vasculitis and to compare them to current fluorescein angiography (FA) findings.

Authors: Julio Zaki Abucham-Neto, André Augusto Miranda Torricelli, Aline Cristina Fioravanti Lui, Sarah Napoli Guimarães, Heloisa Nascimento and Caio Vinícius Regatieri

Resistive index of ophthalmic artery correlates with retinal pigment epithelial alterations on spectral domain optical coherence tomography in diabetic retinopathy

Retinal pigment epithelium (RPE) plays a significant role in maintenance of integrity of retinal photoreceptors and choriocapillaries. RPE derives its blood supply through ophthalmic artery (OA) via choriocapi...

Authors: Manila Khatri, Sandeep Saxena, Apjit Kaur, Shashi K. Bhasker, Manoj Kumar and Carsten H. Meyer

Retinal and choroidal changes in steroid-associated central serous chorioretinopathy

To evaluate the retinal and choroidal alterations in steroid-associated central serous chorioretinopathy (CSC) in comparison to idiopathic CSC.

Authors: Vikas Ambiya, Abhilash Goud, Mohammed Abdul Rasheed, Sankeert Gangakhedkar, Kiran Kumar Vupparaboina and Jay Chhablani

Intravitreal dexamethasone implant versus triamcinolone acetonide for macular oedema of central retinal vein occlusion: quantifying efficacy and safety

Among the retinal vascular diseases, burden of retinal vein occlusion is most common immediately after diabetic retinopathy. Intravitreal corticosteroids are gaining popularity in managing macular edema (ME) ...

Authors: S. K. Mishra, A. Gupta, S. Patyal, S. Kumar, K. Raji, A. Singh and V. Sharma

Vitreous changes after intravitreal bevacizumab monotherapy for retinopathy of prematurity: a case series

Reporting a special clinical finding after intravitreal bevacizumab monotherapy for retinopathy of prematurity.

Authors: Nasser Shoeibi, Seyedeh Maryam Hosseini, Touka Banaee, Mohammad-Reza Ansari-Astaneh, Majid Abrishami and Hamid Ahmadieh

Submillimeter retinoblastoma monitoring following transpupillary thermotherapy using hand-held optical coherence tomography

Precise, submillimeter visualization of retinal microstructures is useful for treatment monitoring of retinoblastoma. Herein, we report the use of hand-held optical coherence tomography (HH-OCT) to document a ...

Authors: Mark McGarrey, Thamolwan Surakiatchanukul and Carol L. Shields

Inverted ILM flap, free ILM flap and conventional ILM peeling for large macular holes

To assess closure rate after a single surgery of large macular holes and their visual recovery in the short term with three different surgical techniques.

Authors: Raul Velez-Montoya, J. Abel Ramirez-Estudillo, Carl Sjoholm-Gomez de Liano, Francisco Bejar-Cornejo, Jorge Sanchez-Ramos, Jose Luis Guerrero-Naranjo, Virgilio Morales-Canton and Sergio E. Hernandez-Da Mota

Consequences of inadvertent intravitreal Mitomycin C injection

Mitomycin C (MMC) as an alkylating agent is miscellaneous an antineoplastic, antibiotic and ophthalmic agent. Here we aim to report a case of inadvertent intravitreal MMC injection instead of Avastin in case o...

Authors: Ahmad Mirshahi, Alireza Lashay, Mohammad Reza Mehrabi Bahar and Mojtaba Abrishami

Early changes in macular optical coherence tomography parameters after Ranibizumab intravitreal injection in patients with exsudative age-related macular degeneration

Evaluation of the impact of different macular optical coherence parameters on visual acuity as early as 1 day after injection of ranibizumab in patients with subfoveal exsudative age-related macular degeneration.

Authors: Nicole Antunes de Almeida and Osias Francisco de Souza

Comparative analysis of choroidal thickness in third trimester pregnant women

The impact of pregnancy on the choroid is still under investigation. The aim of this study is to compare choroidal thickness measurements of healthy pregnant women in the third trimester and healthy non-pregna...

Authors: Camila Zanella Benfica, Teresinha Zanella, Lucas Brandolt Farias, Maria Lúcia Rocha Oppermann, Luis Henrique Santos Canani and Daniel Lavinsky

Macular pigment optical density in a Brazilian sample

To evaluate macular pigment optical density (MPOD) and to identify its determinants in a sample of Brazilian individuals.

Authors: Letícia Pinto Coelho Jorge, Carlos Eduardo Gonçalves Pereira, Eduardo Jorge and Marcos Pereira de Ávila

Jules Gonin and the Nobel Prize: pioneer of retinal detachment surgery who almost received a Nobel Prize in medicine

Authors: Fábio Barreto Morais

Feasibility of using experimental high viscosity silicone oils: a pilot study

Polydimethyl silicones (silicone oils) are used in complex retinal surgeries, including difficult or recurrent retinal detachments, severe eye trauma, and other indications for long term tamponade. Two major ...

Authors: Shira Sheen-Ophir, Mordechai Rosner and Alexander Rubowitz

Autoimmune retinopathy: A Review

Autoimmune retinopathy (AIR) is a rare and still poorly understood immune-mediated disease that may cause inflammation from circulating autoantibodies against the retina. It may be related to history of autoim...

Authors: Aristófanes Mendonça Canamary Jr., Walter Yukihiko Takahashi and Juliana Maria Ferraz Sallum

Idiopathic macular telangiectasis type 2 and co-existent diabetic retinopathy

To study the interaction between idiopathic macular telangiectasis type 2 (MacTel2) and coexistent diabetic retinopathy (DR) during long term follow up.

Authors: Mahima Jhingan, Kerul Marsonia, Dhananjay Shukla, Philip J. Rosenfeld and Jay Chhablani

Retinal malperfusion in albuminuric Type 1 diabetes mellitus patients without clinical signs of diabetic retinopathy: a prospective pilot study

To report fluorescein angiography findings in a group of albuminuric Type 1 diabetes mellitus (T1DM) patients without diabetic retinopathy.

Authors: Fernando Korn Malerbi, Caio Vinicius Regatieri, João Roberto de Sa, Paulo Henrique Morales, Michel Eid Farah and Sergio Atala Dib

Recurrence rate and need for reoperation after surgery with or without internal limiting membrane removal for the treatment of the epiretinal membrane

To compare the recurrence rate and need for reoperation after epiretinal membrane surgery with and without removal of the internal limiting membrane.

Authors: Fernando José De Novelli, Mauro Goldbaum, Mario Luiz Ribeiro Monteiro, Fabio Bom Aggio, Mario Junqueira Nóbrega and Walter Yukihiko Takahashi

Primary rhegmatogenous retinal detachment with inferior retinal breaks postoperative prone positioning results: 1 day versus 7 days

To compare the primary anatomical outcome of pars plana vitrectomy, 360° peripheral endolaser, and 15% octafluoropropane C₃F₈ gas tamponade in patients with uncomplicated rhegmatogenous detachment and inferior re...

Authors: Radwan Ajlan, Jordan Isenberg, Ghassan Cordahi, Renaud Duval, Sébastien Olivier and Flavio Rezende

Subretinal fluid application to close a refractory full thickness macular hole

To close a refractory full thickness macular hole (FTMH) by adjacent subretinal fluid application to release the elastic retina from the retinal pigment epithelium (RPE).

Authors: Carsten H. Meyer, Robert Borny and Nicole Horchi

Heads-up 3D vision system for retinal detachment surgery

Here we present procedural and safety results from our initial experience using 3D heads-up vitrectomy for retinal detachment surgery. The comparison with our outcomes from previous standard surgery shows how ...

Authors: Michele Coppola, Carlo La Spina, Alessandro Rabiolo, Giuseppe Querques and Francesco Bandello

Parafoveolar retinoblastoma regression with foveal preservation following intra-arterial chemotherapy documented on hand-held optical coherence tomography in a newborn

Optical coherence tomography (OCT) has become an invaluable tool in retinoblastoma management, providing submillimeter visualization of tumor control following treatment. Herein, we document OCT-detection of a...

Authors: Vera Yarovaya, Kareem Sioufi and Carol L. Shields

Outcomes of primary endoresection for choroidal melanoma

To review long time treatment results in patients with small or medium sized choroidal melanoma who underwent surgical tumor endoresection as a primary treatment when plaque radiotherapy was unable and patient...

Authors: Andre A. C. Vidoris, Andre Maia, Marcia Lowen, Melina Morales, Jordan Isenberg, Bruno F. Fernandes and Rubens N. Belfort

Development of a new tissue injector for subretinal transplantation of human embryonic stem cell derived retinal pigmented epithelium

Subretinal cell transplantation is a challenging surgical maneuver. This paper describes the preliminary findings of a new tissue injector for subretinal implantation of an ultrathin non-absorbable substrate ...

Authors: Rodrigo A. Brant Fernandes, Francisco R. Stefanini, Paulo Falabella, Michael J. Koss, Trent Wells, Bruno Diniz, Ramiro Ribeiro, Paulo Schor, Mauricio Maia, Fernando M. Penha, David R. Hinton, Yu-Chong Tai and Mark Humayun

Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide

Ophthalmic artery chemosurgery [OAC, intra-arterial chemotherapy (IAC)] was introduced in 2006 as treatment modality for intraocular retinoblastoma. The purpose of this commentary is to retrospectively review ...

Authors: David H. Abramson, Carol L. Shields, Pascal Jabbour, Luiz Fernando Teixeira, José Roberto Falco Fonseca, Marcio Chaves Pedro Marques, Francis L. Munier, Francesco Puccinelli, Theodora Hadjistilianou, Sandra Bracco, Guillermo Chantada, Alejandro Ceciliano and Y. Pierre Gobin

Correction to: pH of anti-VEGF agents in the human vitreous: low impact of very different formulations

After the publication of this article [1], we were made aware that the osmolarity of aflibercept (Eylea) was incorrect and should have been 286 mOsm and not 1000 mOsm. The correct version of Table 1 is shown in t...

Authors: Bianka Sobolewska, Peter Heiduschka, Karl‑Ulrich Bartz‑Schmidt and Focke Ziemssen

Anatomical and functional correlation in Susac syndrome: multimodal imaging assessment

Susac’s syndrome (SuS) is an uncommon disease characterized by retinal microangiopathy that may be assessed more accurately with optical coherence tomography angiography (OCTA), a new imaging technique which p...

Authors: Alexandre G. B. Azevedo, Luiz H. Lima, Léo Müller, Flávio Rezende Filho, Cláudio Zett, André Maia and Luiz Roisman

Twenty-seven-gauge vitrectomy for combined tractional and rhegmatogenous retinal detachment involving the macula associated with proliferative diabetic retinopathy

To report our experience using 27-gauge pars plana vitrectomy (PPV) system for treating patients with combined tractional and rhegmatogenous retinal detachments (CTRRD) involving the macula associated with pro...

Authors: Yousef J. Cruz-Iñigo and María H. Berrocal

Vitrectomy in high myopia: a narrative review

Pathologic myopia is associated with degenerative changes of the globe, especially at the posterior pole. Eyes affected by pathologic myopia have higher odds to undergo posterior segment surgery and, in those ...

Authors: Michele Coppola, Alessandro Rabiolo, Maria Vittoria Cicinelli, Giuseppe Querques and Francesco Bandello

Optical coherence tomography findings in methanol toxicity

Methanol toxicity poses a significant public health problem in developing countries, and in Southeast Asia, where the most common source of poisoning is via adulterated liquor in local drinks. Methanol toxici...

Authors: Kendra A. Klein, Alexis K. Warren, Caroline R. Baumal and Thomas R. Hedges III

Incontinentia pigmenti in a child with suspected retinoblastoma

Incontinentia pigmenti is a rare X-linked dominant syndrome caused by mutation in the NEMO/IKKgamma gene, and characterized by a spectrum of cutaneous, ocular, neurologic and dental abnormalities. In the eye, ...

Authors: Stephanie J. Weiss, Archana Srinivasan, Michael A. Klufas and Carol L. Shields

Gene panel sequencing in Brazilian patients with retinitis pigmentosa

Retinal dystrophies constitute a group of diseases characterized by clinical variability and pronounced genetic heterogeneity. Retinitis pigmentosa is the most common subtype of hereditary retinal dystrophy an...

Authors: Kárita Antunes Costa, Mariana Vallim Salles, Chris Whitebirch, John Chiang and Juliana Maria Ferraz Sallum

Book Review: Anti-VEGF Use in Ophthalmology

This is a review of a book entitled, “Anti-VEGF Use in Ophthalmology,” written by Jay Duker, MD and Michelle Liang, MD. It is an excellent description of the history and development of anti-VEGF agents as wel...

Authors: Robin A. Vora

Net technique for intraocular lens support in aphakia without capsular support

This paper describes a modified surgical technique for intraocular lens implantation in aphakic eyes with no capsular support.

Authors: Fernando José De Novelli, Theodomiro Lourenço Garrido Neto, Gabriel de Sena Rabelo, Marcel Eduardo Blumer, Ricardo Suzuki and Ramon Coral Ghanem