Articles

Treat and extend regimen with aflibercept for chronic central retinal vein occlusions: 2 year results of the NEWTON study

To determine whether aflibercept (Eylea; Regeneron Pharmaceuticals, Inc., Tarrytown, NY) could continue to extend the macular edema free interval in patients on a treat and extend (TAE) with non-ischemic centr...

Authors: Rahul N. Khurana, Louis K. Chang, Alok S. Bansal, James D. Palmer, Chengqing Wu and Mark R. Wieland

Macular hyperpigmentary changes in ABCA4-Stargardt disease

Stargardt disease (STGD) and age-related macular degeneration (AMD) share clinical and pathophysiological features. In AMD, macular hyperpigmentary changes are associated to a worse prognosis. The purpose of t...

Authors: Maria Fernanda Abalem, Amro A. Omari, Dana Schlegel, Naheed W. Khan and Thiran Jayasundera

Anterior chamber paracentesis during intravitreal injections in observational trials: effectiveness and safety and effects

A paracentesis prior to an intravitreal injection is a very safe procedure and can prevent IOP-spikes after injections. As these spikes pose the risk of inducing glaucomatous changes particularly in patients ...

Authors: Sandeep Saxena, Timothy Y. Lai, Hideki Koizumi, Michel E. Farah, Daniela Ferrara, David Pelayes, Tomohito Sato, Carsten H. Meyer and Timothy Murray

Novel stem cell and gene therapy in diabetic retinopathy, age related macular degeneration, and retinitis pigmentosa

Degenerative retinal disease leads to significant visual morbidity worldwide. Diabetic retinopathy and macular degeneration are leading causes of blindness in the developed world. While current therapies for t...

Authors: Parker E. Ludwig, S. Caleb Freeman and Adam C. Janot

Best vitelliform macular dystrophy in a large Brazilian family

To describe the clinical and multimodal imaging findings of a Brazilian family with Best vitelliform macular dystrophy.

Authors: Carolina Pádua Rocha de Souza, Luiz Guilherme Marchesi Mello, Fernando Gomez and Eduardo Morizot

Spontaneous retinal pigment epithelial tear in type 2 choroidal neovascularization: repair mechanisms following anti-VEGF therapy

To report the clinical course and the multimodal retinal imaging of a spontaneous retinal pigment epithelial (RPE) tear in a type 2 choroidal neovascularization (CNV) secondary to age-related macular degenerat...

Authors: Giuseppe Casalino, Vasuki Sivagnanavel, Samir Dowlut, Pearse A. Keane and Usha Chakravarthy

Retinal sensitivity and photoreceptor arrangement changes secondary to congenital simple hamartoma of retinal pigment epithelium

The congenital simple hamartoma of the retinal pigment epithelium is a benign lesion and previous observations with noninvasive imaging have detected potential photoreceptor abnormalities and retinal function ...

Authors: M. W. Rodrigues, D. B. Cavallini, C. Dalloul, C. L. Shields and R. Jorge

Computing uveal melanoma basal diameters: a comparative analysis of several novel techniques with improved accuracy

We sought to compare the accuracy of standard and novel echographic methods for computing intraocular tumor largest basal diameter (LBD).

Authors: Anthony B. Daniels, Kevin K. Veverka, Shriji N. Patel, LuAnne Sculley, Garvin Munn and Jose S. Pulido

Correction to: Sustained and targeted episcleral delivery of celecoxib in a rabbit model of retinal and choroidal neovascularization

Following publication of the original article [1], the authors reported the following changes to the article: 1. The correct name of Dr. De Carvalho is Ricardo A. Pontes de Carvalho.

Authors: Luiz H. Lima, Michel E. Farah, Glenwood Gum, Pamela Ko and Ricardo A. Pontes de Carvalho

Release of silicone oil droplets from syringes

Intravitreal silicone oil droplets have been found in the vitreous. The aim of this study is to compare the rates of silicone oil released by different brands of commonly used syringes for intravitreal injecti...

Authors: Gustavo Barreto Melo, Celso de Souza Dias Junior, Mariana Reis Carvalho, Alexandre Lima Cardoso, Fábio Barreto Morais, Ana Carolina Migliorini Figueira, Acácio Alves Souza Lima Filho, Geoffrey Guy Emerson and Maurício Maia

Quantitative measurement of vascular density and flow using optical coherence tomography angiography (OCTA) in patients with central retinal vein occlusion: Can OCTA help in distinguishing ischemic from non-ischemic type?

To evaluate microvascular changes and quantitative parameters in patients with central retinal vein occlusion (CRVO) by using optical coherence tomography angiography (OCTA) and finding difference between pres...

Authors: Alireza Khodabandeh, Kiyanoosh Shahraki, Ramak Roohipoor, Hamid Riazi-Esfahani, Mehdi Yaseri, Houshang Faghihi and Fatemeh Bazvand

Multicolor imaging in choroidal osteomas

To describe the multicolour (MC) imaging characteristics associated with choroidal osteomas (CO) and their secondary complications.

Authors: Ramesh Venkatesh, Bharathi Bavaharan, Naresh Kumar Yadav, Kumar Saurabh, Priya Srinivasan, Padmalini Mahendradas, Vishma Prabhu and Rupak Roy

Cuticular drusen associated with aneurysmal type 1 neovascularization (polypoidal choroidal vasculopathy)

Aneurysmal type 1 neovascularization (AT1) is a term recently introduced to better describe the aneurysmal dilatation that may arise from neovascular lesions, more commonly known as polypoidal choroidal vascul...

Authors: Serena Fragiotta, Talia R. Kaden and K. Bailey Freund

Multimodal imaging in a patient with Prader–Willi syndrome

Prader–Willi syndrome (PWS) is a genetic disease caused by loss of expression of the paternally inherited copy of several genes on the long arm of chromosome 15. Ophthalmic manifestations of PWS include strabi...

Authors: Mohamed A. Hamid, Mitul C. Mehta and Baruch D. Kuppermann

Multimodal imaging of retinal metastasis masquerading as an acute retinal necrosis

To report the multimodal imaging and histology of a case of metastatic esophageal cancer with vitreoretinal involvement resembling acute retinal necrosis (ARN) in a patient receiving systemic chemotherapy.

Authors: Fukutaro Mano, Stephen A. LoBue, Kuo-Chung Chang and Tomiya Mano

Ocular kinetics and safety of intravitreally injected angiotensin converting enzyme inhibitor lisinopril

The study investigated the intravitreal safety and vitreous disposition of lisinopril, an angiotensin converting enzyme inhibitor in rabbits for its projected use in retinopathy.

Authors: Madhu Nath, Nabanita Halder, Parijat Chandra, Sundararajan Baskar Singh, Ashok Kumar Deorari, Atul Kumar and Thirumurthy Velpandian

The outcomes of epiretinal membrane peeling in patients with foveal herniation

To evaluate the surgical outcomes of vitrectomy in patients with foveal herniation associated with epiretinal membrane (ERM).

Authors: Abdullah Ozkaya, Gurkan Erdogan and Gokhan Demir

Central subfield thickness and cube average thickness as bioimaging biomarkers for ellipsoid zone disruption in diabetic retinopathy

To evaluate the association of central subfield thickness (CST) and cube average thickness (CAT) with ellipsoid zone (EZ) disruption on spectral domain optical coherence tomography (SD-OCT) in patients of diab...

Authors: Sukriti Ahuja, Sandeep Saxena, Carsten H. Meyer, Jagjit S. Gilhotra and Levent Akduman

Evaluation of aflibercept and ziv-aflibercept binding affinity to vascular endothelial growth factor, stability and sterility after compounding

To investigate the binding affinity, stability, and sterility of aflibercept and ziv-aflibercept to vascular endothelial growth factor (Holash et al. in Proc Natl Acad Sci USA 99(17):11393–11398, 2002.

Authors: Julia de Lima Farah, Ronaldo Sano, Ieda Maria Longo Maugéri, Daniela Teixeira, Mayari Eika Ishimura, Gabriela Martins, Lycia M. J. Mimica, Cely Barreto da Silva, Carsten H. Meyer, João Rafael de Oliveira Dias, Gabriel Costa de Andrade and Michel Eid Farah

Subconjunctival 0.1% epinephrine versus placebo in maintenance of mydriasis during vitrectomy: a randomized controlled trial

Pupil dilation and mydriasis maintenance throughout vitreoretinal surgeries are important to allow satisfactory fundus visualization and reduce risk of complications. The purpose of this study is to evaluate t...

Authors: Rafael B. de Araújo, Breno M. S. Azevedo, Thais S. Andrade, Maria F. Abalem, Mário L. R. Monteiro and Pedro C. Carricondo

Diurnal variation of choriocapillaris vessel flow density in normal subjects measured using optical coherence tomography angiography

Vessel flow density (VFD) may provide important information regarding perfusion status. Diurnal variation in VFD of choriocapillaris has not been reported in literature. In the index study, optical coherence t...

Authors: Salman Sarwar, Muhammad Hassan, Mohamed K. Soliman, Muhammad Sohail Halim, Mohammad Ali Sadiq, Rubbia Afridi, Aniruddha Agarwal, Diana V. Do, Quan Dong Nguyen and Yasir J. Sepah

Peripheral retinal nonperfusion using widefield imaging with von Hippel-Lindau disease

To describe a case of von Hippel-Lindau disease with peripheral retinal nonperfusion.

Authors: Jose S. Pulido, Lauren A. Dalvin, Timothy W. Olsen, Fukutaro Mano, Michael Yu and Carol L. Shields

Burkholderia cepacia, a cause of post pars plana vitrectomy silicone oil related endophthalmitis: clinico-pathological presentation and outcome of management

To report the long-term outcome of the management of a series of culture proven post pars plana vitrectomy endophthalmitis in which the infective agent was in the silicone oil used as an endotamponade. The iso...

Authors: Ogugua Ndubuisi Okonkwo, Adekunle Olubola Hassan, Olufemi Oderinlo and Michael Ekuoba Gyasi

Eplerenone in the treatment of central serous chorioretinopathy: a review of the literature

The purpose of this review is to examine the role of eplerenone in the treatment of central serous chorioretinopathy (CSCR).

Authors: Irini Chatziralli, Aikaterini Vlachodimitropoulou, Chrysoula Daoula, Christina Vrettou, Eleni Galani, George Theodossiadis and Panagiotis Theodossiadis

Change in subfoveal choroidal thickness in diabetes and in various grades of diabetic retinopathy

To evaluate subfoveal choroidal thickness (SFCT) change in diabetes and in various grades of diabetic retinopathy (DR) in comparison to age-matched healthy subjects.

Authors: Vikas Ambiya, Ashok Kumar, V. K. Baranwal, Gaurav Kapoor, Amit Arora, Nidhi Kalra and Jyoti Sharma

Retina and glaucoma: surgical complications

The close structural and microcirculatory co-relation between anterior and posterior segments of eye make them very vulnerable to complications when one of them is affected surgically. With the advent of anti-...

Authors: Niroj Kumar Sahoo, Pasyanthi Balijepalli, Sumit Randhir Singh, Mahima Jhingan, Sirisha Senthil and Jay Chhablani

Clinical course of acute zonal occult outer retinopathy complicated by choroidal neovascularization

To report the clinical course and multimodal imaging features of acute zonal occult outer retinopathy (AZOOR) complicated by choroidal neovascularization (CNV) treated with anti-vascular endothelial growth fac...

Authors: Ugo Introini, Giuseppe Casalino, Elona Dhrami-Gavazi, Sri Krishna Mukkamala, Sarah Mrejen, Hermann Schubert, Salomon Y. Cohen, Claudio Azzolini, Francesco Bandello, Stanley Chang and Lawrence A. Yannuzzi

Direct navigated laser photocoagulation as primary treatment for retinal arterial macroaneurysms

To compare the efficacy and safety of conventional and navigated laser photocoagulation as the primary treatment option for retinal arteriolar macroaneurysm (RAM).

Authors: Dmitrii S. Maltsev, Alexei N. Kulikov, Bhushan Uplanchiwar, Luiz H. Lima and Jay Chhablani

Multimodal imaging in choroidal osteoma

To describe characteristics of choroidal osteomas (CO), using ocular ultrasound, fluorescein angiography, ultra-widefield retinal imaging, ultra-widefield autofluorescence, optical coherence tomography, enhanc...

Authors: Francisco Olguin-Manríquez, Ana Bety Enríquez, Nicolás Crim, Miroslava Meraz-Gutierrez, Vidal Soberón-Ventura, Ismael Ávila, Virgilio Morales-Canton and Juan Manuel Jimenez-Sierra

Sustained and targeted episcleral delivery of celecoxib in a rabbit model of retinal and choroidal neovascularization

To evaluate the efficacy of selective episcleral delivery of celecoxib formulated in a sustained-release episcleral exoplant on a model of retinal and choroidal neovascularization induced in rabbits by subreti...

Authors: Luiz H. Lima, Michel E. Farah, Glenwood Gum, Pamela Ko and Ricardo A. de Carvalho

Iodate induced toxic retinopathy: a case report

Iodine deficiency is a common preventable cause of intellectual and developmental disabilities. Iodine in the form of potassium iodate is added to the common salt under the National Iodine Deficiency Disorder ...

Authors: Y. C. Venu Gopal Reddy, Anuj Sharma, Adheesh P. Shetty and Syed Mohideen Abdul Kader

Acute retinal vein occlusion and cystic fibrosis

The ocular manifestations of cystic fibrosis typically present with surface irritation or nyctalopia due to Vitamin A deficiency, however, there have been two previous reports of patients with cystic fibrosis ...

Authors: Matthew R. Starr, Suzanne M. Norby, John P. Scott and Sophie J. Bakri

Idiopathic full thickness macular hole in a 10-year-old girl

Macular holes in children are generally associated with trauma.

Authors: Li-Anne S. Lim, Guillermo Fernandez-Sanz, Steven Levasseur, John R. Grigg and Alex P. Hunyor

Dexamethasone implant in silicone oil: in vitro behavior

To determine the effect of the silicone on the dexamethasone intravitreal implant.

Authors: Erick Omar Flores-Villalobos, J. Abel Ramírez-Estudillo, Atzin Robles-Contreras and Jacqueline L. Oliva-Ramírez

Gamma Knife radiosurgery for locally recurrent choroidal melanoma following plaque radiotherapy

For the majority of eyes with choroidal melanoma, radiation therapy is the treatment of choice. Local recurrence after radiation therapy can occur, however, and when it does, salvaging the globe with useful vi...

Authors: Osama A. Sorour, John E. Mignano and Jay S. Duker

The utility of ultra-widefield fluorescein angiography in pediatric retinal diseases

Ultra-widefield angiography is the latest technology in the evolution of fundus fluorescein angiography. With the ability to capture up to 200° of the fundus in a single image, far peripheral retinal pathology...

Authors: Charles M. Calvo and Mary Elizabeth Hartnett

Correction to: The diagnosis and treatment of primary vitreoretinal lymphoma: a review

Following publication of the original article [1], the authors reported that one of the authors’ name is spelled incorrectly. In this correction, the incorrect and correct author names are shown.

Authors: Jose S. Pulido, Patrick B. Johnston, Grzegorz S. Nowakowski, Alessia Castellino and Harish Raja

Incidence and risk factors for retinopathy of prematurity: a retrospective cohort study

Advances in neonatal care promoted increased survival rates of preterm infants, with a consequent increase in the number of children affected by retinopathy of prematurity (ROP). This study estimates the incid...

Authors: André Moraes Freitas, Ricardo Mörschbächer, Mariana R. Thorell and Ernani Luis Rhoden

Re: Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide

Authors: Sameh E. Soliman, Helen Dimaras, Brenda Gallie and Furqan Shaikh

Vinorelbine-induced regression of a choroidal metastasis from primary breast carcinoma

Various therapeutic options exist to treat choroidal metastatic lesions. However, they are all associated with potential long-term adverse effects. This case report discusses a case of choroidal metastasis fr...

Authors: Malvika Arya and Jay S. Duker

The diagnosis and treatment of primary vitreoretinal lymphoma: a review

To describe the recent diagnostic and treatment options for the most predominant form of primary vitreoretinal lymphoma (PVRL), namely diffuse large B cell lymphoma. This is mainly based on the experience at t...

Authors: Jose S. Pulido, Patrick B. Johnston, Grzegorz S. Nowakowski, Alessia Castellino and Harish Raja

Choroidal infarction following ophthalmic artery chemotherapy

Methylenetetrahydrofolate reductase (MTHFR) genetic mutations and intra-procedural inhaled nitrous oxide (N₂O) independently increase blood levels of homocysteine, a compound associated with thrombosis. Patients ...

Authors: Kelley J. Bohm, Y. Pierre Gobin, Jasmine H. Francis, Gabrielle McInerney, Anahita Dabo-Trubelja, Paul H. Dalecki, Brian P. Marr and David H. Abramson

Choroidal thickness changes measured by enhanced depth imaging optical coherence tomography in third trimester pregnant women

The aim of this article is to underline the effect of pregnancy on the variations of choroidal thickness caused by hormonal and haemodynamic changes.

Authors: Lorenzo Ferro Desideri, Fabio Barra, Simone Ferrero and Aldo Vagge

Comparison between optical coherence tomography angiography and fluorescein angiography findings in retinal vasculitis

To describe optical coherence tomography angiography (OCT-A) findings in patients with retinal vasculitis and to compare them to current fluorescein angiography (FA) findings.

Authors: Julio Zaki Abucham-Neto, André Augusto Miranda Torricelli, Aline Cristina Fioravanti Lui, Sarah Napoli Guimarães, Heloisa Nascimento and Caio Vinícius Regatieri

Resistive index of ophthalmic artery correlates with retinal pigment epithelial alterations on spectral domain optical coherence tomography in diabetic retinopathy

Retinal pigment epithelium (RPE) plays a significant role in maintenance of integrity of retinal photoreceptors and choriocapillaries. RPE derives its blood supply through ophthalmic artery (OA) via choriocapi...

Authors: Manila Khatri, Sandeep Saxena, Apjit Kaur, Shashi K. Bhasker, Manoj Kumar and Carsten H. Meyer

Retinal and choroidal changes in steroid-associated central serous chorioretinopathy

To evaluate the retinal and choroidal alterations in steroid-associated central serous chorioretinopathy (CSC) in comparison to idiopathic CSC.

Authors: Vikas Ambiya, Abhilash Goud, Mohammed Abdul Rasheed, Sankeert Gangakhedkar, Kiran Kumar Vupparaboina and Jay Chhablani

Intravitreal dexamethasone implant versus triamcinolone acetonide for macular oedema of central retinal vein occlusion: quantifying efficacy and safety

Among the retinal vascular diseases, burden of retinal vein occlusion is most common immediately after diabetic retinopathy. Intravitreal corticosteroids are gaining popularity in managing macular edema (ME) ...

Authors: S. K. Mishra, A. Gupta, S. Patyal, S. Kumar, K. Raji, A. Singh and V. Sharma

Vitreous changes after intravitreal bevacizumab monotherapy for retinopathy of prematurity: a case series

Reporting a special clinical finding after intravitreal bevacizumab monotherapy for retinopathy of prematurity.

Authors: Nasser Shoeibi, Seyedeh Maryam Hosseini, Touka Banaee, Mohammad-Reza Ansari-Astaneh, Majid Abrishami and Hamid Ahmadieh

Submillimeter retinoblastoma monitoring following transpupillary thermotherapy using hand-held optical coherence tomography

Precise, submillimeter visualization of retinal microstructures is useful for treatment monitoring of retinoblastoma. Herein, we report the use of hand-held optical coherence tomography (HH-OCT) to document a ...

Authors: Mark McGarrey, Thamolwan Surakiatchanukul and Carol L. Shields

Inverted ILM flap, free ILM flap and conventional ILM peeling for large macular holes

To assess closure rate after a single surgery of large macular holes and their visual recovery in the short term with three different surgical techniques.

Authors: Raul Velez-Montoya, J. Abel Ramirez-Estudillo, Carl Sjoholm-Gomez de Liano, Francisco Bejar-Cornejo, Jorge Sanchez-Ramos, Jose Luis Guerrero-Naranjo, Virgilio Morales-Canton and Sergio E. Hernandez-Da Mota