Articles

Macular edema after rhegmatogenous retinal detachment repair: risk factors, OCT analysis, and treatment responses

To investigate risk factors, imaging characteristics, and treatment responses of cystoid macular edema (CME) after rhegmatogenous retinal detachment (RRD) repair.

Authors: Cameron Pole, Ismael Chehaibou, Andrea Govetto, Sean Garrity, Steven D. Schwartz and Jean-Pierre Hubschman

Comparison of modern high-speed vitrectomy systems and the advantages of using dual-bladed probes

This study analyzes the efficiency of different vitrectomy systems and compares single with double-bladed cutters.

Authors: R. Oravecz, D. Uthoff, N. Schrage and R. M. Dutescu

Epiretinal membrane surgery outcome in eyes with abnormalities of the central bouquet

Clinical studies have shown that epiretinal membranes (ERM) as well as abnormalities of the central foveal bouquet (CB) can be classified in different stages according to their morphological appearance. Furthe...

Authors: Max P. Brinkmann, Stephan Michels, Carolin Brinkmann, Felix Rommel, Mahdy Ranjbar, Nicole Graf Johansen and Matthias Becker

Peripheral retinal leakage in POEMS syndrome

POEMS (polyneuropathy, organomegaly, endocrinopathy, myeloma protein, skin changes) syndrome is a rare blood disorder with multi-system involvement. The cause is unknown. It is marked by elevated plasma cells,...

Authors: Andrew Rising Carey and Praveen Jeyaseelan

Ocular complications following intravitreal bevacizumab injection for retinopathy of prematurity and assessment of risk factors

Laser ablation of the avascular peripheral retina has been the standard method of ROP treatment. Intravitreal anti-VEGF is useful in the management of ROP patients, especially for aggressive posterior ROP. How...

Authors: Fatemeh Bazvand, Hamid Riazi-Esfahani, Ahmad Mirshahi, Alireza Khodabande, Hasan Khojastheh, Afsar Dastjani Farahani, Ramak Roohipourmoallai, Marjan Imani, Hooshang Faghihi, Nazanin Ebrahimi Adib and Mohammadreza Mehrabi Bahar

Real-life outcomes of subthreshold laser therapy for diabetic macular edema

Diabetic macular edema (DME) is a major cause of visual impairment and its treatment is a public health challenge. Even though anti-angiogenic drugs are the gold-standard treatment, they are not ideal and subt...

Authors: Renato M. Passos, Fernando K. Malerbi, Marindia Rocha, Maurício Maia and Michel E. Farah

Choriocapillaris Island: an optical coherence tomography angiography finding observed in central serous chorioretinopathy

To report the observation of the choriocapillaris island (CCI) on optical coherence tomography angiography (OCTA) in eyes with active central serous chorioretinopathy (CSCR), and to investigate its associated ...

Authors: Rania G. Estawro, Alaa E. Fayed, Teresa K. Gerges and Dina N. Baddar

Endophthalmitis after pars plana vitrectomy with reused single-use devices: a 13-year retrospective study

To describe the incidence, clinical characteristics, and treatment outcomes of endophthalmitis after pars plana vitrectomy (PPV) with recycled single-use devices. The recommended sterilization process as well ...

Authors: Sukhum Silpa-archa, Kwanchanoke Kumsiang and Janine M. Preble

Unilateral macular serpiginous-like choroiditis as the initial manifestation of presumed ocular tuberculosis

Classic serpiginous choroiditis (SC) usually begins in the peripapillary area and spreads centrifugally, however, in some patients, the lesion can arise in the macular region. An association between lesions re...

Authors: Raul N. G. Vianna, Vinicius Vanzan, Maria Luisa Gois da Fonsêca and Leonardo Cravo

Macular and choroidal thicknesses in a healthy Hispanic population evaluated by high-definition spectral-domain optical coherence tomography (SD-OCT)

To report normal values of macular and choroidal thickness obtained from a healthy Hispanic population using Optovue (Optovue Inc, Freemont CA, USA) spectral domain optical coherence tomography (SD-OCT).

Authors: Diana A. Cortés, Daniela Roca, Pedro Iván Navarro and Francisco J. Rodríguez

Retraction Note to: Pharmacological agents in development for diabetic macular edema

The authors have retracted this article [1] for legal reasons. Therefore the contents of this article are no longer available. The authors have been invited to submit a new version of the article. All authors ...

Authors: Mohammad Ali Sadiq, Muhammad Sohail Halim, Muha mmad Hassan, Neil Onghanseng, Irmak Karaca, Aniruddha Agarwal, Rubbia Afridi, Yasir J. Sepah, Diana V. Do and Quan Dong Nguyen

Autoimmune retinopathy: findings and limitations from optical coherence tomography angiography

To report novel findings and limitations from optical coherence tomography angiography (OCTA) in the evaluation of autoimmune retinopathy (AIR).

Authors: Joseph Raevis, Tyler Etheridge, Spencer Cleland and Mihai Mititelu

Anatomical and functional outcomes of subthreshold micropulse laser versus intravitreal ranibizumab injection in treatment of diabetic macular edema

To compare the therapeutic effects of subthreshold micropulse laser (SML) versus intravitreal injection of ranibizumab in treatment of diabetic macular edema (DME) both anatomically using optical coherence tom...

Authors: Amr Abdelrahman, Wagiha Massoud, Ahmed Mohamed Kamal Elshafei, Mahmoud Genidy and Raafat Mohyeldeen Abdelrahman Abdallah

Vascular density of optic nerve head in diabetic retinopathy using optical coherence tomography angiography

To measure optic nerve head (ONH) blood perfusion using optical coherence tomography angiography (OCTA) at various stages of diabetic retinopathy (DR).

Authors: Fariba Ghassemi, Sahar Berijani, Ramak Roohipoor, Masoumeh Mohebbi, Ameneh Babeli, Alireza Gholizadeh and Siamak Sabour

Choroidal vascularization and adrenergic innervation qualitative findings obtained with induced fluorescence preparations and optical coherence tomography angiography: possible correlations and perspectives

Recent advances in optical coherence tomography (OCT) technology allow a more accurate choroidal visualization. The aim of this study is to provide histochemical analysis with induced fluorescence images of th...

Authors: Raffaele Nuzzi, Federico Tridico, Alessandro Marchese and Francesco Bandello

Autologous full-thickness retinal transplant for refractory large macular holes

Despite the constant refinement of techniques and surgical aids, extremely large and refractory macular holes continue to have poor surgical outcomes with the current standard of care. The objective of the pre...

Authors: Sergio Rojas-Juárez, Javier Cisneros-Cortés, Abel Ramirez-Estudillo and Raul Velez-Montoya

Near-infrared reflectance imaging of neovascularization in proliferative diabetic retinopathy

Blood is one of the main absorbers in the near-infrared spectrum and thus retinal vessels appear dark in near-infrared reflectance (NIR) images. Proliferative diabetic retinopathy (PDR) is characterized by abn...

Authors: Sara Vaz-Pereira, Manuel Monteiro-Grillo and Michael Engelbert

Lyophilized amniotic membrane patch (LAMPatch) as a replacement of tamponades in the treatment of primary rhegmatogenous retinal detachment

The basis of retinal detachment repair is sealing the retinal breaks. In order to seal the retinal breaks, chorioretinal adhesion around these lesions has to be achieved. Laser retinopexy is not immediate thus...

Authors: Mario Saravia, Luis Zeman and Alejandro Berra

Use of an ultra-clean air flow for surgical field asepsis when performing intravitreous injections in an ambulatory surgical environment

Intravitreal injection of medications is one of the most common procedures performed in ophthalmology. Intravitreal anti-VEGF agents are currently the chosen treatment for ocular fundus diseases, including age...

Authors: Renata Moreto, Francyne Veiga Cyrino and Rodrigo Jorge

25 vs. 27-gauge micro-incision vitrectomy surgery for visually significant macular membranes and full-thickness macular holes: a retrospective study

To evaluate visual and safety outcomes for 25-gauge (25G) and 27-gauge (27G) micro-incision vitrectomy platforms (MIVS) for the treatment of epiretinal membrane and full-thickness macular holes.

Authors: Gordon T. Brown, Sangeethabalasri Pugazhendhi, Robert M. Beardsley, John W. Karth, Peter A. Karth and Allan A. Hunter

A practical guide to optical coherence tomography angiography interpretation

Optical coherence tomography angiography (OCTA) can image the retinal vasculature in vivo, without the need for contrast dye. This technology has been commercially available since 2014, however, much of its us...

Authors: Eugenia Custo Greig, Jay S. Duker and Nadia K. Waheed

Bartonella hanselae retinitis patient evaluated with multimodal retinal exams

Cat scratch disease is a systemic infectious illness caused by the bacterium Bartonella henselae. The most common ophthalmological involvement due to infection by Bartonella is Parinaud oculoglandular syndrome, w...

Authors: Paulo Alberto Cervi Rosa, Luis Filipe Nakayama, Vinicius Campos Bergamo, Dante Akira Kondo Kuroiwa and Nilva Simeren Bueno de Moraes

Optic coherence tomography features of subretinal vitreous substitutes

To draw comparisons between spectral domain optic coherence tomography (SD-OCT) features of subretinal silicon oil (SO), perfluoro-n-octane (PFO) or C3F8 gas.

Authors: Leandro Cabral Zacharias, Epitácio Dias da Silva Neto, Taurino dos Santos Rodrigues Neto, José Ronaldo Lima de Carvalho Júnior, Rony Carlos Preti, Leonardo Provetti Cunha, Tatiana Tanaka and Mário Luiz Ribeiro Monteiro

Endoscope-assisted scleral buckle procedure

Retinal reattachment surgery requires clear visualization of the posterior segment for optimal outcomes. Select patients may benefit most from primary scleral buckling without vitrectomy, but lack adequate pos...

Authors: Sean M. Platt and Andrew J. Barkmeier

Epidemiology of uveal melanoma in Brazil

To report the prevalence of uveal melanoma in a Hospital database in Brazil over the period of 16 years (2000 to 2016).

Authors: Evandro Lucena, Daniel Cohen Goldemberg, Luiz Claudio Santos Thuler and Andreia Cristina de Melo

Association of macular perfusion status with microvascular parameters up to the far periphery in diabetic retinopathy using multimodal imaging

The aim of our study was to investigate a possible association between macular perfusion status and retinal ischemia and leakage up to far peripheral retinal areas in eyes with early to advanced stages of diab...

Authors: Dorottya Hajdu, Aleksandra Sedova, Felix Datlinger, Julia Hafner, Irene Steiner, Katharina Kriechbaum, Christoph Scholda, Stefan Sacu, Ursula Schmidt-Erfurth and Andreas Pollreisz

Optical coherence tomography angiography measured area of retinal neovascularization is predictive of treatment response and progression of disease in patients with proliferative diabetic retinopathy

The purpose of this study was to evaluate the area of retinal neovascularization in patients with treatment-naïve proliferative diabetic retinopathy (PDR) as measured by optical coherence tomography angiograph...

Authors: Anna Stage Vergmann, Kristian Tølbøl Sørensen, Thomas Lee Torp, Ryo Kawasaki, Tien Wong, Tunde Peto and Jakob Grauslund

The Tie2 signaling pathway in retinal vascular diseases: a novel therapeutic target in the eye

Retinal vascular diseases such as neovascular age-related macular degeneration, diabetic retinopathy and/or diabetic macular edema, and retinal vein occlusion with macular edema—share several key pathophysiolo...

Authors: Quan Dong Nguyen, Jeffrey S. Heier, Diana V. Do, Adam C. Mirando, Niranjan B. Pandey, Huan Sheng and Theresa Heah

Posterior segment inflammatory outcomes assessed using fluorescein angiography in the STOP-UVEITIS study

Although fluorescein angiography (FA) is a frequently used imaging modality in patients with non-infectious uveitis (NIU), it has not been reliably used for objective assessment of posterior segment inflammato...

Authors: Mohammad Ali Sadiq, Muhammad Hassan, Rubbia Afridi, Muhammad Sohail Halim, Diana V. Do, Yasir J. Sepah and Quan Dong Nguyen

Concept and application of relaxing radial retinectomy for retinal detachment with advanced proliferative vitreo-retinopathy

To revisit the concept of retinectomy and the theory of mechanical forces on the retina occurring in rhegmatogenous retinal detachment (RRD) and to describe the potential application of radial retinectomy in R...

Authors: Waldensius Girsang, Dwi C. R. Sari, Wahyu Srigutomo, Tjahjono D. Gondhowiardjo and Muhammad B. Sasongko

Lamellar macular holes: evolving concepts and propensity for progression to full thickness macular hole

Currently the term lamellar macular hole (LMH) alludes to a wide spectrum of macular conditions including distinct clinical entities with different pathomorphologies. Classifications into subtypes, tractional ...

Authors: Salim Zafar Asaad

A perspective on retina education through social media

Since the beginning of the Internet, new ways of providing medical education have emerged. Social media networks are one of the most influential communication tools and allow content sharing, collaborative mod...

Authors: Ricardo Luz Leitão Guerra

Pedicle internal limiting membrane flap technique for very large macular holes: a preliminary report

Conventional vitrectomy technique for macular hole surgery has a good outcome in small and medium macular holes, but for very large macular holes (minimum linear diameter higher than 700 μm) other techniques w...

Authors: José Edísio da Silva Tavares Neto, Igor Neves Coelho, Rodrigo Jorge, David Leonardo Cruvinel Isaac and Marcos Pereira de Ávila

A guarded light pipe for direct visualization during primary scleral buckling on the Ngenuity platform

Visualization during scleral buckling is traditionally achieved via indirect ophthalmoscopy. Recent advances have utilized the surgical microscope and a 25 gauge cannula-based endoillumination system, also kno...

Authors: Joshua S. Agranat, Vivian P. Douglas, Konstantinos A. A. Douglas and John B. Miller

Supine positioning after vitrectomy for rhegmatogenous retinal detachments with inferior retinal breaks

To evaluate the effectiveness of face up position (FUP) following pars plana vitrectomy (PPV) and silicone oil injection in cases of rhegmatogenous retinal detachment (RRD) with multiple peripheral and inferio...

Authors: Amr Mohammed Elsayed Abdelkader and Hossam Youssef Abouelkheir

Preclinical assessment of intravitreal ramucirumab: in vitro and in vivo safety profile

Anti-angiogenic drugs remain the mainstay therapy for several vascular retinal pathologies. The repurposing of approved anti-angiogenic drugs for use in ophthalmology can increase therapeutic options and reduc...

Authors: Jarbas Emílio de Moraes Neto, Felipe Pereira, Raquel Leão Neves, Nilana Meza Tenório de Barros, Cristiane Damas Gil, Arthur Gustavo Fernandes, Sung Eun Song Watanabe, Carsten Helmut Meyer, Michel Eid Farah and Eduardo Buchele Rodrigues

The long-term effects of anti-vascular endothelial growth factor therapy on the optical coherence tomography angiographic appearance of neovascularization in age-related macular degeneration

The short-term effects of anti-vascular endothelial growth factor (anti-VEGF) treatment on macular neovascularization (MNV) morphology is well described, but long-term studies on morphologic changes and correl...

Authors: Emily S. Levine, Eugenia Custo Greig, Luísa S. M. Mendonça, Shilpa Gulati, Ivana N. Despotovic, A. Yasin Alibhai, Eric Moult, Nora Muakkassa, Maddalena Quaranta-El Maftouhi, Adil El Maftouhi, Usha Chakravarthy, James G. Fujimoto, Caroline R. Baumal, Andre J. Witkin, Jay S. Duker, M. Elizabeth Hartnett…

Effects of phosphodiesterase type 5 inhibitors on choroid and ocular vasculature: a literature review

To provide information on the effects of phosphodiesterase type 5 (PDE5) inhibitors on choroidal vessels and central serous chorioretinopathy (CSC) and possible implications for development of exudative age-re...

Authors: Natasha Ferreira Santos da Cruz, Murilo Ubukata Polizelli, Laís Maia Cezar, Emmerson B. Cardoso, Fernando Penha, Michel Eid Farah, Eduardo B. Rodrigues and Eduardo A. Novais

OCT changes of idiopathic epiretinal membrane after cataract surgery

We reviewed our experience in the management of cataract and idiopatic epiretinal membrane surgeries at the Humanitas Research Institute–Milan, Italy- over the past 3 years.

Authors: Jose Luis Vallejo-Garcia, Mary Romano, Luca Pagano, Alessio Montericcio, Alfredo Borgia, Emanuela Morenghi and Paolo Vinciguerra

Reliability of foveal avascular zone measurements in eyes with retinal vein occlusion using optical coherence tomography angiography

To evaluate the reliability of foveal avascular zone (FAZ) area measurements using optical coherence tomography angiography (OCTA) in eyes with retinal vein occlusion (RVO).

Authors: Bruno Mauricio Rodrigues de Oliveira, Luis Filipe Nakayama, Bruno Rebello de Godoy, Alexandre Gomes Bortoloti de Azevedo, Flavio Eduardo Hirai and Somaia Mitne

Unilateral morning glory disc anomaly in a patient with prenatal Zika virus exposure

To report a case of morning glory disc anomaly (MGDA) in a pediatric patient with prenatal Zika virus (ZIKV) exposure.

Authors: Sofía M. Muns, Mónica P. González, Victor M. Villegas, Gabriela de la Vega, Camila V. Ventura and Audina M. Berrocal

Endoscopy-assisted vitrectomy vs. vitrectomy alone: comparative study in complex retinal detachment with proliferative vitreoretinopathy

Recurrent retinal detachment (RD) is still a widespread event despite the therapeutic options available. Proliferative vitreoretinopoathy (PVR) is one of the main causes of redetachment. Little is known about ...

Authors: Flavio A. Rezende, Natalia Vila and Emmanouil Rampakakis

Successful growth of fresh retinoblastoma cells in chorioallantoic membrane

The authors developed a retinoblastoma model using fresh harvested cells from an enucleated eye that were transplanted in chick embryos (chorioallantoic membrane model). The transplanted embryos were treated w...

Authors: Silvia L. Fialho, Bárbara R. Silvestrini, Juliana Vieira, Mayara R. B. Paiva, Luciana M. Silva, Fernando Chahud, Armando Silva-Cunha, Zelia M. Correa and Rodrigo Jorge

Safety and tolerability evaluation after repeated intravitreal injections of a humanized anti-VEGF-A monoclonal antibody (PRO-169) versus ranibizumab in New Zealand white rabbits

To evaluate the retinal toxicity after repeated intravitreal injections of a humanized anti-VEGF-A monoclonal antibody (PRO-169) versus ranibizumab in New Zealand white (NZW) rabbit eyes.

Authors: Leopoldo Baiza-Durán, Alejandra Sánchez-Ríos, Joel González-Barón, Oscar Olvera-Montaño, Elba Correa-Gallegos, Andrea Navarro-Sánchez and Patricia Muñoz-Villegas

Identification of epiretinal proliferation in various retinal diseases and vitreoretinal interface disorders

To describe the presence of epiretinal proliferation in eyes with various retinal and vitreoretinal interface conditions.

Authors: Ismael Chehaibou, Moritz Pettenkofer, Andrea Govetto, Gilad Rabina, SriniVas R. Sadda and Jean-Pierre Hubschman

New findings useful for clinical practice using swept-source optical coherence tomography angiography in the follow-up of active ocular toxoplasmosis

Ocular toxoplasmosis is one of the most common causes of intraocular inflammation and posterior uveitis in immunocompetent patients. This paper aims to investigate swept-source optical coherence tomography ang...

Authors: João Rafael de Oliveira Dias, Camila Campelo, Eduardo Amorim Novais, Gabriel Costa de Andrade, Paula Marinho, Yusláy Fernández Zamora, Luciana Finamor Peixoto, Maurício Maia, Heloísa Nascimento and Rubens Belfort Jr.

Pharmacological agents in development for diabetic macular edema

Authors: Mohammad Ali Sadiq, Muhammad Sohail Halim, Muhammad Hassan, Neil Onghanseng, Irmak Karaca, Aniruddha Agarwal, Rubbia Afridi, Yasir J. Sepah, Diana V. Do and Quan Dong Nguyen

Morphology of partial-thickness macular defects: presumed roles of Müller cells and tissue layer interfaces of low mechanical stability

The pathogenesis of partial-thickness macular defects and the role of Müller glial cells in the development of such defects are not well understood. We document the morphological characteristics of various typ...

Authors: Andreas Bringmann, Jan Darius Unterlauft, Renate Wiedemann, Matus Rehak and Peter Wiedemann

Surgical management of submacular hemorrhage due to n-AMD: a comparison of three surgical methods

To compare and assess the efficacy of three surgical methods for the treatment of acute submacular hemorrhage (ASH): pneumatic displacement with C2F6, in combination with intravitreal injection of bevacizumab ...

Authors: Carsten Grohmann, Spyridon Dimopoulos, Karl Ulrich Bartz-Schmidt, Philipp Schindler, Toam Katz, Martin S. Spitzer and Christos Skevas

Optical coherence tomography angiography using the black-and-white pixel binarization histogram software: a new technique for evaluating healing of macular holes in two surgical techniques

Many factors can influence the functional outcomes of macular hole surgery and some studies have tried to describe anatomical features that could predict successful treatment. The purpose of this study is to d...

Authors: Oswaldo Ferreira Moura Brasil, Mariana Kawamuro, Denise Pardini Marinho, Bruna Trench Maia, Murilo Ubukata Polizelli, Gabriel Pipolo, Natalia Trench Maia, Rodrigo Dompieri, Natasha Ferreira Santos da Cruz and Mauricio Maia